Matthew R Smith Selected Research

Docetaxel (Taxotere)

4/2024	Deep and Durable Prostate-specific Antigen Response to Darolutamide with Androgen Deprivation Therapy and Docetaxel, and Association with Clinical Outcomes for Patients with High- or Low-volume Metastatic Hormone-sensitive Prostate Cancer: Analyses of the Randomized Phase 3 ARASENS Study.
10/2023	Efficacy and Safety of Darolutamide in Combination With Androgen-Deprivation Therapy and Docetaxel in Black Patients From the Randomized ARASENS Trial.
10/2023	Darolutamide Plus Androgen-Deprivation Therapy and Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer by Disease Volume and Risk Subgroups in the Phase III ARASENS Trial.
1/2022	Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer.
1/2020	Cabozantinib for Progressive Metastatic Castration-resistant Prostate Cancer Following Docetaxel: Combined Analysis of Two Phase 3 Trials.
10/2018	Clinical Development of Darolutamide: A Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
12/2014	Population pharmacokinetic analysis of abiraterone in chemotherapy-naïve and docetaxel-treated patients with metastatic castration-resistant prostate cancer.
10/2014	Prognostic impact of the neutrophil-to-lymphocyte ratio in men with metastatic castration-resistant prostate cancer.
5/2014	Enzalutamide monotherapy in hormone-naive prostate cancer: primary analysis of an open-label, single-arm, phase 2 study.
3/2010	Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.

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Matthew R Smith Research Topics

Disease

197	Prostatic Neoplasms (Prostate Cancer) 05/2024 - 01/2002
66	Neoplasm Metastasis (Metastasis) 03/2024 - 02/2002
41	Neoplasms (Cancer) 12/2023 - 01/2002
22	Osteoporosis 11/2019 - 01/2002
19	Pain (Aches) 12/2023 - 12/2003
18	Cardiovascular Diseases (Cardiovascular Disease) 07/2013 - 11/2004
16	Insulin Resistance 04/2014 - 11/2004
15	Disease Progression 01/2024 - 12/2003
12	Fatigue 02/2024 - 07/2004
10	Breast Neoplasms (Breast Cancer) 07/2023 - 01/2005
10	Obesity 01/2017 - 11/2004
8	Myocardial Infarction 07/2013 - 09/2006
7	Hypertension (High Blood Pressure) 12/2023 - 01/2009
7	Bone Diseases (Bone Disease) 07/2012 - 01/2005
7	Carcinoma (Carcinomatosis) 03/2006 - 11/2002
6	Circulating Neoplastic Cells 02/2024 - 03/2010
6	Bone Fractures (Bone Fracture) 12/2023 - 07/2008
6	Anemia 01/2023 - 07/2008
6	Coronary Disease (Coronary Heart Disease) 02/2016 - 09/2006
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2015 - 06/2007
6	Flushing 01/2013 - 07/2004
6	Bone Resorption 01/2012 - 05/2003
6	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2011 - 05/2004
4	Heart Diseases (Heart Disease) 12/2023 - 12/2010
4	Exanthema (Rash) 12/2023 - 04/2018
4	Diabetes Mellitus 01/2009 - 11/2004
3	Inflammation (Inflammations) 11/2023 - 01/2012
3	Gynecomastia 05/2015 - 05/2009
3	Spontaneous Fractures (Pathological Fracture) 11/2012 - 12/2003
3	Metabolic Bone Diseases (Osteopenia) 07/2012 - 10/2009
3	Lung Neoplasms (Lung Cancer) 05/2009 - 01/2005
3	Renal Cell Carcinoma (Grawitz Tumor) 01/2005 - 01/2002
2	Weight Loss (Weight Reduction) 12/2023 - 01/2020
2	Osteoporotic Fractures 11/2019 - 09/2011
2	Overweight 01/2017 - 01/2007

Drug/Important Bio-Agent (IBA)

114	AndrogensIBA 05/2024 - 01/2002
38	Prostate-Specific Antigen (Semenogelase)IBA 04/2024 - 07/2003
31	Hormones (Hormone)IBA 05/2024 - 01/2003
30	Gonadotropin-Releasing Hormone (GnRH)FDA Link 03/2014 - 02/2002
25	Zoledronic Acid (Zometa)FDA Link 12/2016 - 06/2003
23	Diphosphonates (Bisphosphonates)IBA 11/2019 - 01/2003
18	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2003
18	Denosumab FDA Link 11/2019 - 12/2005
16	darolutamideIBA 04/2024 - 10/2018
16	Abiraterone AcetateIBA 01/2023 - 03/2010
15	Androgen Receptors (Androgen Receptor)IBA 03/2024 - 03/2010
14	apalutamideIBA 12/2023 - 12/2016
11	Docetaxel (Taxotere)FDA Link 04/2024 - 01/2005
10	Toremifene (Fareston)FDA Link 01/2013 - 01/2002
9	Prednisone (Sone)FDA LinkGeneric 01/2020 - 03/2010
9	LipidsIBA 12/2019 - 04/2008
8	cabozantinibIBA 01/2020 - 01/2013
8	Triglycerides (Triacylglycerol)IBA 03/2014 - 02/2008
7	Leuprolide (Lupron)FDA LinkGeneric 12/2010 - 02/2002
6	Testosterone (Sustanon)FDA Link 01/2018 - 07/2003
6	abirateroneIBA 01/2018 - 01/2013
6	Pamidronate (Aredia)FDA LinkGeneric 08/2009 - 06/2003
5	Radium-223IBA 02/2024 - 11/2015
5	enzalutamideIBA 01/2024 - 05/2014
5	Monoclonal AntibodiesIBA 10/2013 - 08/2009
5	HDL CholesterolIBA 01/2013 - 06/2007
5	collagen type I trimeric cross-linked peptideIBA 12/2011 - 06/2006
5	bicalutamide (Casodex)FDA LinkGeneric 02/2008 - 01/2003
4	Alkaline PhosphataseIBA 01/2020 - 12/2003
4	Tyrosine Kinase InhibitorsIBA 01/2020 - 11/2012
4	Androgen Receptor AntagonistsIBA 10/2019 - 12/2016
4	Selective Estrogen Receptor Modulators (SERM)IBA 05/2015 - 01/2005
4	Narcotics (Narcotic Analgesics)IBA 02/2015 - 11/2012
4	Analgesics (Analgesic Drugs)IBA 10/2014 - 12/2003
4	RANK LigandIBA 10/2013 - 08/2009
4	MineralsIBA 01/2013 - 10/2010
4	Collagen Type I (Type I Collagen)IBA 07/2012 - 03/2007
4	Estrogens (Estrogen)FDA Link 01/2012 - 01/2002
4	Goserelin (Zoladex)FDA Link 01/2009 - 12/2007
3	RNA (Ribonucleic Acid)IBA 02/2024 - 03/2010
3	RadiopharmaceuticalsIBA 01/2024 - 09/2011
3	niraparibIBA 07/2023 - 01/2022
3	MicronutrientsIBA 01/2018 - 11/2015
3	LDL CholesterolIBA 01/2013 - 04/2008
3	Aromatase InhibitorsIBA 01/2012 - 11/2002
3	CholesterolIBA 02/2010 - 04/2008
3	Therapeutic UsesIBA 10/2006 - 01/2005
2	AntigensIBA 03/2024 - 12/2019
2	Antineoplastic Agents (Antineoplastics)IBA 10/2023 - 12/2003
2	taxaneIBA 07/2023 - 01/2022
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 10/2019
2	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 05/2015
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2020 - 08/2007
2	Hemoglobins (Hemoglobin)IBA 01/2020 - 08/2007
2	LigandsIBA 12/2019 - 03/2010

Therapy/Procedure

144	Therapeutics 05/2024 - 01/2002
79	Castration 04/2024 - 07/2003
22	Drug Therapy (Chemotherapy) 07/2023 - 01/2005
11	Radiotherapy 01/2017 - 12/2003
8	Prostatectomy (Retropubic Prostatectomy) 01/2017 - 10/2004
7	Orchiectomy (Orchidectomy) 03/2014 - 04/2004
4	Drug Tapering 11/2015 - 01/2013
3	Duration of Therapy 01/2016 - 11/2005
2	Aftercare (After-Treatment) 01/2017 - 01/2017